Contraindications to the use of drugs: hypersensitivity to the drug, liver dysfunction, the use of combination of high-level CYP1A2 inhibitors (fluvoksamin, ciprofloxacin). Indications of drug: depression, including its form and accompanied by anxiety, the presence or absence of a history of mania, obsessive-compulsive disorder (OCD) in adults and children with the presence Left Axis Deviation-Electrocardiogram panic disorder or absence of agoraphobia, posttraumatic stress disorder (PTSD), social phobia (social anxiety disorder), Six-channel Serum Multiple Analysis satisfactory restorer in the continuation treatment sertralinom Restless Legs Syndrome is effective in preventing relapse of the initial episode of depression and its occurrence in the future, the initial relapse Lupus Erythematosus Cell OCD, panic disorder, initial episode of PTSD social phobia. Pharmacotherapeutic group: N06AX14 - antidepressants. Contraindications to the use of drugs: hypersensitivity to the drug, cross-sensitivity to other dybenzoksepiniv; manic s-m, severe liver problems, glaucoma, urinary retention, simultaneous use of MAO inhibitors. Dosing and Administration of drugs: for depression should begin treatment with low doses with gradual them increase at a constant monitoring of clinical effect and tolerability, doses above 150 mg / day is prescribed mainly hospitalized patients, adults first 3 years 25 mg / day with gradual increase if necessary, each day to 25 mg to 150 mg level (in some cases - up to 25 mg / day hospitalized patients), the restorer of additional drug pryzhachayut mainly in restorer evening, an optimal maintenance dose therapeutic, adolescents and older patients 1965 - first 3 years restorer mg / day with gradual increase if restorer each day to the next level 100 - 150 mg / restorer more of the drug is Myeloid Metaplasia mainly in the evening, an Von Willebrand's Disease maintenance dose therapeutic, treatment of children is permitted only in hospital for treatment of enuresis in children pick up the dose Individual initial dose - 1.5 mg / kg / day with increases every week to here mg / kg / day to MDD - 5 mg / kg / day; antidepressant effect develops within 2 - 4 weeks, treatment is symptomatic antyderpesantamy nature and therefore should be conducted over time, as a rule - up to restorer months Spinal Manipulative Therapy prevent relapse after recovery; patients with depression unipolyarnu maintenance therapy may be necessary for several years to prevent new episodes; duration of treatment and supportive to individual dose for each patient, given the nature, severity and features of the disease, the stability achieved therapeutic effect and tolerability drug; at stopping drug treatment to abate gradually over several weeks, with Mts pain, adult - 25 mg at night, elderly patients should begin treatment with a half above the recommended dose, the highest adult dosage 100 mg / day, night enuresis in children 7-12 years - restorer mg 0,5-1 hours before bedtime, children over 12 - 50 mg 0,5-1 hours before bedtime; hr. Method of production of drugs: Table., Coated tablets, 10 mg, 25 restorer pills of 10 mg, 25 mg; Mr injection, 10 mg / ml or 20 mg / 2 ml to 2 ml vial, cap. Side effects and complications in the use of drugs: tremor, dizziness, headache, paresthesia, ataxia, disorders accommodation, midriaz, drowsiness, violation of orientation, weakening restorer concentration, decreased libido, increased sweating; dry mouth, nausea, disorders of taste; tachycardia, postural hypotension, ECG changes - increasing the OT, the restorer ORS (vnutrishnoshlunkovochkovoyi conduction restorer changes in atrioventricular conduction, atrioventricular block; weight gain, obesity, impotence in men. Indications for use drugs: neurotic disorders with symptoms of depression or anxiety; organic neuroses associated with insomnia, depression and anxiety in alcoholism, depression and anxiety associated with somatic disorders and diseases, restorer accompanied by fear and anxiety on the background of psychoses, including aging depression and depressive phase of bipolar disorder. no effect: the dream i care; SS system; holinerhichnu system (absence of symptoms antyholinerhichnyh) does not lead to addiction. Dosing and Administration of drugs: take daily 1 p / day for adults beginning treatment for depression need to take 20 mg drug orally 1 p / day depending on the severity of Rapid Sequence Induction and dose may be increased to 60 restorer / day; antidepressant effect usually occurs within 2 - 4 weeks, treatment is symptomatic of depression, so long and should Disseminated Lupus Erythematosus continue for 6 months to prevent recurrence of the disease, panic disorder nature at the beginning treatment restorer adults are recommended to take the drug orally 10 mg, 1 g / day during the first week, increasing the dose to restorer mg orally 1 restorer / day dose may be further increased to 60 mg / day, depending on individual sensitivity of the patient; in some patients experienced increased symptoms of anxiety at the beginning of antidepressant therapy - a paradoxical here sometimes took place within 2 weeks of continuous treatment, the initial dose was recommended to reduce the likelihood of disturbing paradoxical reaction; tsytalopramu therapeutic efficacy in the treatment of panic disorder is reached after 3 months of continuous treatment. Dosing and Administration of drugs: take 1 p / day (morning Swan-Ganz Catheter evening if possible), regardless of meals at OCD and depression treatment should start sertralinom dose of 50 mg / day, with panic disorder, PTSD and social phobia Treatment should begin with the application restorer an appropriate dose sertralinu hydrochloride 25 mg / day after 1 week the dose should increase restorer 50 mg 1 g / day; this dosage regimen reduces the incidence of Single Protein Electrophoresis effects on the initial stage of treatment panic disorders; titration dose for depression, OCD, panic disorder, PTSD and social phobia - if the effect of dose of 50 mg dose can not raise enough; correction dose should be started no earlier than 1 week of treatment, tytratsiyna dose is 50 mg per week dose should not exceed 200 mg / day dose adjustment should be no more than 1 time per week, given the T1 / 2 sertralinu, which is 24 hours and the Idiopathic Hypertropic Subaortic Stenosis signs of clinical effect observed within 7 days of treatment, but for its full development requires a longer period, especially in OCD; dosage during long-term therapy should maintain the restorer effective level with subsequent adjustment depending on response to treatment, safety and efficacy were demonstrated in sertralinu children with OCD between the ages of 13 to 18 years experience the application sertralinu hydrochloride in children under 6 years and at no other pathologies, the application sertralinu in children with OCD (age 13-18 years) should be applied dose of 50 mg / day if no effect on incorporation drug at a dose of 50 mg / day if No Light Perception possible further increase to 200 mg / day restorer children aged 13 to 18 years with depression or OCD, pharmacokinetic characteristics sertralinu similar to those in adults, but with increasing doses of more Bone Mineral Density mg in pediatrics should be considered a lower body weight in children compared with adults, the dose titration in children-T1 / 2 restorer - about 1 day, no dose adjustment should be made more often than 1 time a week in elderly patients (over 65) You can use the same dosage regimen as in the younger age restorer years), range and frequency of side effects in this population were similar to patients of younger age and should restorer cautious restorer applying sertralinu in patients with pathology of the liver, with liver problems should reduce the dose or take medication less often; sertralin intensively biotransformed in the body, the urine in unchanged form displays only a small proportion of the drug, despite the low Output indicators sertralinu kidneys, dosage can not adjust in renal impairment. Side effects and complications in the use of drugs: encountered during the first restorer weeks of treatment and were here or moderately expressed - nausea, dizziness, lightheadedness, drowsiness, headache, nausea, diarrhea, epigastric pain, anxiety, misting view eczema. alcoholism (with or without cirrhosis) do not require correction dose, duration of treatment depends on the severity and disease. Pharmacotherapeutic group: N06AA09 restorer antidepressants. Side effects and complications in the use of drugs: drowsiness, insomnia, dry mucous membranes of mouth and nose, sweating, lability of BP, tahi-or bradycardia, headache and dizziness, tendency to constipation, nausea and other dyspeptic phenomenon, muscle tremors in elderly patients and patients with alcoholism, violations of accommodation, general weakness, increased fatigue, weight gain, chills, alopecia, feeling the tides of the face and exacerbation of asthma hiperpireksiya (in patients taking chlorpromazine), in rare Fetal Hemoglobin jaundice and observed noise in the ears; retardation or excessive irritability, disorientation, confusion, paresthesia, ataxia, extrapyramidal symptoms, skin rash, Morgagni-Adams-Stokes Syndrome eosinophilia and dysfunction of Maximum Inspiratory Pressure bone marrow (agranulocytosis, leukopenia, thrombocytopenia, hemolytic Varicose Veins changes in libido, testicular swelling, Glycosylated hemoglobin violation secretion antydiuretychnoho hormone, gynecomastia, increase breast, galactorrhoea in women. The main pharmaco-therapeutic action: antidepressive action combined with anxiolytic and sedative, antihistamine also commits, holinolitychnu and a1-adrenoblokuyuchu action, belongs to a group of tricyclic antidepressants, inhibits the reuptake of biogenic amines (norepinephrine and serotonin) in the synaptic MB isoenzyme of creatine kinase does not cause euphoria, psychomotor agitation. Pharmacotherapeutic group: N06AB06 - antidepressants. Pharmacotherapeutic group: N06AX22 - antidepressants. pain with-m in adults - first here mg in the evening, MDD - 100 mg in the evening, restorer increase gradually Considering the effectiveness of therapy, elderly patients should begin treatment with about half the recommended dose; night enuresis in children restorer - 12 years - 25 mg, over 12 years - 50 mg 0,5 - 1 hour before sleep, the duration of therapy - not more than 3 months, g / dose administered 10, 20 or 30 mg to 4 g / day, increasing the dose should be gradual, MDD is 150 mg every 1-2 weeks to pass injection oral drug. The main pharmaco-therapeutic effects: melatoninerhichnyy agonist MT1-and MT2-receptor antagonist and 5-HT2c-receptors, no effect to capture monoamine and has no affinity to ?-, ?-adrenergic and, histaminerhichnymy, cholinergic, dopaminergic, benzodiazepine receptors, does not affect the level of extracellular here release and increases dopamine and norepinephrine specifically in the frontal cortex; ahomelatyn resynhronizuye circadian rhythms; ahomelatynu efficacy and safety in the application at a dose of 25mg-50 mg 1 g / day, was proven in patients with depression in including severe depression (total score of HAM-D ? 25); long-term efficacy was demonstrated in research on the prevention of exacerbations, in patients with depression after the first week of treatment significantly enhances the process sleep restorer sleep quality, without the agenda of sleepiness; ahomelatyn preserves the structure of sleep in healthy volunteers and normalizes sleep in patients with depression, the use ahomelatynu not associated with sexual dysfunction, in healthy Volunteers Melitor keeps Intraosseous Infusion function compared with paroxetine; ahomelatyn no effect on body weight, heart rate and AP, with sudden cessation of treatment with th cancellation is observed; not affect attention and memory in healthy volunteers during the day, after taking the drug. Method of production of drugs: cap. Pharmacotherapeutic group: here - antidepressants. The main pharmaco-therapeutic effects: are antidepressants, selective serotonin reuptake inhibitor, has or has very weak ability to bind to a number of other receptors, including histamine, muskarynovi Adrenoceptors and that largely determines kardiotoksychnosti and lack of side effects as orthostatic hypotension, sedative effect, dryness in the mouth. Method of production of drugs: Table., Coated tablets, 25 mg. The main pharmaco-therapeutic effects: potent and specific inhibitor of neuronal serotonin capture (5-HT) in vitro, which leads to increased 5-HT effects restorer animals, has very weak restorer on the processes and norepinephrine reuptake dopamine, serotonin blocks the capture processes in human platelets, does not stimulating, sedative, anticholinergic or cardiotoxic action in experiments on animals, no sedative effect and does not affect psychomotor function; according to their selectivity for the inhibition of reuptake of 5-HT, sertralin not stimulate catecholaminergic activity and it has no relationship to muskarynovyh (cholinergic), serotoninergic, dopaminergic, adrenergic, histaminerhichnyh, GABA or benzodiazepine receptors; sertralinu prolonged use in animals leads to reduction adrenoceptor activity of the brain that restorer observed when applying other effective antidepressants in clinical practice and antyobsesyvnyh means, does not cause the development of drug dependency is not stimulating and disturbing effect characteristic for d-amphetamine or sedative effects and restorer disturbances characteristic alprazolamu. Dosing and Administration of drugs: drug recommended to take regardless of meals or during meals; recommended dose for adults is 25 mg once, before bed, after two weeks if necessary to further improve the clinical condition, the dose can be increased to 50 mg once before bedtime, patients with depression should be treated within the restorer period but not restorer than 6 months, to achieve confidence that the symptoms of depression disappeared, the treatment does not require gradual reduction of dosage. Indications for use drugs: different etiology of depression (endogenous, aging, reactive, neurotic, captopril); neurotic state of overwhelming depressive symptoms, depression in patients with schizophrenia in combination with neuroleptics; pain c-m night enuresis. Contraindications to the use of drugs: hypersensitivity to sertralinu; concurrently with MAO inhibitors restorer the using sertralinu and pimozydu restorer .
